Family name :
HEAPE
First names : Martin Anthony (Tony)
Date of birth : 1st November 1956
Place of birth :
Nationality : British
Professional Address
Department of Anatomy &
PL
FIN-90014 University of
Tel. (+358) 08 537 51 97
Fax. (+358) 08 537 51 72
CURRICULUM VITAE
EDUCATION, DIPLOMAS AND TRAINING
1981 B. Sc. Biochemistry.
1982 M. Sc. Biochemistry.
1983 Licenciate of Cellular and Molecular Biology
Research.
1988 Ph. D. Biochemistry.
1997 Docent Biochemistry/Neurochemistry of
POSTDOCTORAL RESEARCH POSITIONS AND APPOINTMENTS
1988 - 1990 Scientist (CR 2, CNRS) in the
Laboratory of Membrane Biogenesis at the I.B.C.N. (
1990 - 1992 Postdoctoral leave at the Biocenter Oulu and Department of Clinical
Chemistry (
1992 - 1995 Senior Scientist (CR 1, CNRS) in the Laboratory of Membrane
Biogenesis (
1995 - 2003 Senior Scientist in the Department of Pathology (
2003 - 2004 Senior Assistant/Scientist in the Department of Anatomy & Cell
Biology (
2004 - Research Fellow of the
SUMMARY OF RESEARCH ACTIVITY
LABORATORY
OF MEMBRANE BIOGENESIS OF THE C.N.R.S. (
Developmental and in vivo
approaches to myelin biogenesis in the peripheral nervous system and its
pathological modifications in the case of a dysmyelinating
mutant. Three principal topics:
1. A comparative developmental study of lipid accumulation in the sciatic
nerves of normal and Trembler mutant mice during the period of active myelinogenesis. This study allowed to conclude that the
original process taking place in the neuropathy affecting the Trembler mouse
peripheral nervous system is one of dysmyelination ,
while demyelination is a secondary event.
2. An in vivo study of lipid metabolism in the peripheral nervous system. The
results of this study demonstrated that the ceramide
pathway and the Kennedy pathway are, respectively, the major contributors to sphingolipid and glycerolipid
biosynthesis in myelinated peripheral nerves in vivo
and in situ. We also showed that galactosyl-cerebroside
biosynthesis in the Trembler mouse nerves was severely diminished and that the cerebrosides that were synthesized were abnormal. The
deficient synthesis of these myelin lipids was shown to result from anomalies
in the substrate supply, rather than to defective activities of the enzyme
systems in the mutant’s peripheral nerves.
3. An in vivo study of intracellular, intermembrane
transports of lipids from their sites of synthesis to the myelin in mouse
sciatic nerves. This study allowed to demonstrate an intermembrane
movement of lipids from a membrane fraction presenting characteristics of a
site of lipid synthesis, to myelin membranes.
BIOCENTER
The effect of the human
Prostate-specific Acid Phosphatase [hPAP] on growth factor-dependent tyrosine phosphorylation in androgen-dependent and
androgen-insensitive prostate cancer epithelial cell lines.
DEPARTMENT
OF PATHOLOGY (
In the Dept. of Pathology (
DEPARTMENT
OF ANATOMY & CELL BIOLOGY (
In the Dept. of Anatomy (
OTHER
PROFESSIONAL ACTIVITIES/SOCIETIES
Member of the Society for Neurosciences.
Member of the
Member of the Peripheral Nerve Society.
Member of the Brain Research Society of Finland
Coordinator of the Myelination
& Myelin Disease Consortium (MMDC)
LANGUAGES
Perfectly bilingual: English -
French (spoken - written - read). A LITTLE Finnish (getting
better every day, sometimes).
Myelin Group
Publications Tony's Other Publications Views
and Opinions
The Myelin Group pages
Group
Members Who did What
Photos Collaborators
Links