Molecular Physiology

 

Many diseases are related to unequal input/output balance, imbalance/lack of macronutrients, toxic compounds or physical inactivity. The different organs involved in keeping homeostasis (brain-gut/microbiome-fat-liver-muscle) are tightly communicating with each other via peptides, proteins, nutrients and nerves (adipokines, hepatokines, myokines, gut peptides, neurotransmitters). Understanding the communication of this organ cross talk might decipher the molecular mechanisms in the pathogenesis of metabolic diseases like diabetes and obesity/metabolic syndrome. Furthermore, the increased energy storages lead to inflammation affecting the signaling cascades. Our mission is to elucidate the communication signals and pathways which might lead to novel therapeutic targets and new strategies for the prevention of these diseases.

Member of the Nordic centre of Excellence for Nutrition Food and Health: SYSDIET - Systems biology in controlled dietary interventions and cohort studies.

 

Our group is also part of the project "Molecular Determinants of the Metabolic Syndrome" at the Biocenter of Oulu directed by Markku Savolainen, Marjo-Riitta Järvelin and Karl-Heinz Herzig.

 

Member in DynaHealth - a European Horizon 2020 funded research project focused on healthy and active ageing through reducing the risks of obesity and type 2 diabetes

 

 

 

 

 

 

 

Last update 25.05.2016

Webmaster: kari.makela@oulu.fi