| PARPs in PDB |
|---|
PARP-1 [ARTD1]
Many domains
4DQY,
4OPX,
4OQA,
4OQB
PARP domain:
2RD6,
2RCW,
1WOK,
1UK0,
1UK1,
3GJW,
3GN7,
3L3L,
3L3M,
4HHY,
4HHZ,
4GV7,
4L6S,
4R6E,
4R5W,
4UXB,
4UND,
4PJT,
4ZZZ,
5A00,
4XHU
other
PARP domain (chicken):
2PAW,
1PAX,
2PAX,
3PAX,
4PAX,
1EFY,
1A26
Zn1:
2DMJ
Zn2:
2CS2
Zn3:
2RIQ,
2JVN
WGR:
2CR9
BRCT:
2COK,
2LE0
other:
4AV1
|
PARP-2 [ARTD2]
PARP domain:
3KCZ,
3KJD,
4TJV,
4ZZX,
4ZZY
PARP domain (mouse):
1GS0
|
PARP-3 [ARTD3]
PARP domain:
3C4H,
3C49,
3CE0,
3FHB,
4GV4,
4GV2,
4GV0
4L7L,
4L6Z,
4L7N,
4L70,
4L7O,
4L7U,
4L7R,
4L7P
WGR domain:
2EOC
|
PARP-5a [ARTD5]
PARP domain:
2RF5,
3UDD,
3UH2,
3UH4,
4DVI,
4I9I,
3W51,
4IUE,
4K4F,
4K4E,
4MT9, 4MSG, 4MSK,
4N3R,
4N4T,
4N4V,
4W5S,
4W6E,
4TOR,
4TOS,
4OA/,
4W5S/,
4W6E/
Ankyrin:
3UTM (mouse)
|
PARP-5b [ARTD6]
PARP domain:
3KR7,
3KR8,
3MHJ,
3MHK,
3P0N,
3P0P,
3P0Q,
3U9H,
3UA9,
3U9Y,
4AVW,
4AVU,
4HKI,
4HKK,
4HKN,
4HL5,
4HLH,
4HLG,
4HLF,
4HLK,
4HLM,
4HMH,
4HYF,
4J3M,
4J3L,
4J21,
4J22,
4J1Z,
4BFP,
4L2G,
4L2F,
4L2K,
4KZL,
4L0V,
4KZU,
4KZQ,
4L09,
4L0T,
4BS4,
4L0B,
4L10,
4L0I,
4L31,
4L32,
4L0S,
4L33,
4L34,
3BU3,
4BU5,
4BU6,
4BU7,
4BU8,
4BU9,
4BUD,
4BUE,
4BUF,
4BUI,
4BUS,
4BUT,
4BUU,
4BUV,
4BUW,
4BUX,
4BUY,
4M7B,
4BJ9,
4BJB,
4BJC,
4UX4,
4W5I,
4W5S,
4UVS,
4UVT,
4UVU,
4UVV,
4UVW,
4UVX,
4UVY,
4UVZ,
4UVL,
4UVN,
4UVO,
4UVP,
4TKF,
4TKG,
4TKI,
4PNT,
4PNS,
4TJU,
4TJY,
4TK0,
4TK5,
4PNN,
4PNQ,
4PNR,
4PNM,
4PML,
5C5P,
5C5Q,
5C5R
ARC4 domain:
3TWQ,
3TWR,
3TWS,
3TWT,
3TWU,
3TWV,
3TWW,
3TWX,
2Y0I
|
|
Structure, Function and Selective Inhibition of Human ADP-ribosyltransferases
Our research group is interested in interfacing between experimental work (bioassays and crystallography) and computational methods in order to study and develop small molecule inhibitors. Our main focus is in the development of selective inhibitors for the enzymes of human poly(ADP-ribose) polymerase family. Structures are available for several catalytic domains of this 17 membered enzyme family. We are working in parallel in developing assays suitable for high throughput screening of inhibitors and use structural information for the more rational design. We use x-ray crystallography and modeling to identify and rationalise structure-activity relationships of compounds. We are also interested in other collaborative projects related to protein structures especially in the field of signaling through ADP-ribosylation.
More information about the project can can be found here.
|
| People:
|
 | Lari Lehtiö
PhD Biochemistry
Group leader
|
 | Teemu Haikarainen
PhD Biochemistry
|
 | Harikanth Venkannagari
MSc Molecular Biology
PhD student
|
 |
Ezeogo Obaji
MSc Biochemistry
PhD student
|
 |
Yves Nkizinkiko
MSc Biochemistry
PhD student
|
 |
Vesa Hautaniemi
BSc Biochemistry
MSc student
|
 |
Alexander Ignatev
PhD Organic Chemistry
|
 |
Mirko Maksimainen
PhD Biochemistry
|
 |
Sudarshan Murthy
MSc Biochemistry
PhD student
|
 |
Yashwanth Ashok
MSc Biochemistry
|
|
Former members:
|
Margherita Miele - 2015, Erasmus trainee
|
Ekaterina Biterova - 2013-2014, Postdoc
|
Mohit Narwal - 2009-2014, PhD student
|
Elvis Ongey - 2013, Research assistant
|
Saman Nosheen - 2012-2013, MSc student
|
Yves Nkizinkiko - 2011-2012, MSc student and research assistant
|
Hao-Wei Lee - 2012, MSc Biochemistry, Researcher
|
Mariana Schlesinger - 2012,MSc Molecular Biology, Visiting PhD student (EMBO fellow)
|
Utkarsh Trivedi - 2011,Trainee,MSc student at IIT Roorkee
|
Salomé Vilchez Larrea - 2010, MSc Biotechnology, Visiting PhD student (EMBO fellow)
|
Robin Sundström - 2009, BSc Biosciences, Research assistant
|
Funding:
|
Biocenter Oulu
|
Academy of Finland
|
Jane & Aatos Erkko foundation
|
Sigrid Jusélius foundation
|
Tor, Joe and Pentti Borg foundation
|
National Graduate School in Informational and Structural Biology (MN)
|
EMBO short term fellowship (SVL,MS)
|
Centre for International Mobility (HV)
|
|
|
|
|
| | Contact: |
Lari Lehtiö
Biocenter Oulu
Faculty of Biochemistry and Molecular Medicine
University of Oulu
Aapistie 7 B
FIN-90230 Oulu
Finland
Mailing address:
P.O. BOX 5400
FIN-90014 University of Oulu
Finland
lari.lehtio-at-oulu.fi
|
Publications
Latest structure in the PDB
|
|
|
Updated 30.9.2014
|
| mARTs in PDB |
|---|
|
PARP-9 [ARTD9]
macro domain:
5AIL
|
PARP-10 [ARTD10]
PARP domain:
3HKV
RRM domain:
2DHX
|
|
PARP-11 [ARTD11]
WWE domain:
2DK6
|
PARP-12 [ARTD12]
PARP domain:
2PQF
|
PARP-13 [ARTD13]
PARP domain:
2X5Y,
4X52
|
PARP-14 [ARTD8]
PARP domain:
3GOY,
3SMJ,
3SMI,
3SE2,
4F1L,
4F1Q,
4PY4
macro domain:
3Q71,
3Q6Z,
3VFQ,
4D86,
4ABK,
4ABL,
RRM domain:
1X5P
WWE domain:
1XR4
|
PARP-15 [ARTD7]
PARP domain:
3GEY,
3BLJ,
4F0E
macro domain 2:
3KH6,
3V2B
|
PARP-16 [ARTD15]
PARP domain:
4F0D
|
|