PARPs in PDB

PARP-1 [ARTD1]
Many domains 4DQY
PARP domain: 2RD6, 2RCW, 1WOK, 1UK0, 1UK1, 3GJW, 3GN7, 3L3L, 3L3M, other
PARP domain (chicken): 2PAW, 1PAX, 2PAX, 3PAX, 4PAX, 1EFY, 1A26
Zn1: 2DMJ
Zn2: 2CS2
Zn3: 2RIQ, 2JVN
WGR: 2CR9
BRCT: 2COK, 2LE0
other: 4AV1

PARP-2 [ARTD2]
PARP domain: 3KCZ, 3KJD PARP domain (mouse): 1GS0

PARP-3 [ARTD3]
PARP domain: 3C4H, 3C49, 3CE0, 3FHB WGR domain: 2EOC

PARP-5a [ARTD5]
PARP domain: 2RF5, 3UDD, 3UH2, 3UH4, 4DVI
Ankyrin: 3UTM (mouse)

PARP-5b [ARTD6]
PARP domain: 1KR7, 3KR8, 3MHJ, 3MHK, 3P0N, 3P0P, 3P0Q, 3U9H, 3UA9, 3U9Y, 4AVW, 4AVU ARC4 domain: 3TWQ, 3TWR, 3TWS, 3TWT, 3TWU, 3TWV, 3TWW, 3TWX, 2Y0I

Structure, Function and Selective Inhibition of Human ADP-ribosyltransferases

Our research group is interested in interfacing between experimental work (bioassays and crystallography) and computational methods in order to study and develop small molecule inhibitors. Our main focus is in the development of selective inhibitors for the enzymes of human poly(ADP-ribose) polymerase family. Structures are available for several catalytic domains of this 17 membered enzyme family. We are working in parallel in developing assays suitable for high throughput screening of inhibitors and use structural information for the more rational design. We use x-ray crystallography and modeling to identify and rationalise structure-activity relationships of compounds. We are also interested in other collaborative projects related to protein structures especially in the field of signaling through ADP-ribosylation. More information about the project can can be found here.

People:
Lari Lehtiö
PhD Biochemistry
Group leader
 Teemu Haikarainen
PhD Biochemistry
Mohit Narwal
MSc Biotechnology
PhD student
 Harikanth Venkannagari
MSc Molecular Biology
PhD student

Hao-Wei Lee
MSc Biochemistry
Mariana Schlesinger
MSc Molecular Biology
Visiting PhD student
(EMBO fellow)

Saman Nosheen
MSc Biochemistry
MSc student
Yves Nkizinkiko
MSc student

Former members:
Utkarsh Trivedi - 2011,Trainee,MSc student at IIT Roorkee
Salomé Vilchez Larrea - 2010, MSc Biotechnology, Visiting PhD student (EMBO fellow)
Robin Sundström - 2009, BSc Biosciences, Research assistant

Funding:
Biocenter Oulu
Academy of Finland
Sigrid Jusélius foundation
Tor, Joe and Pentti Borg foundation
National Graduate School in Informational and Structural Biology (MN)
EMBO short term fellowship (SVL,MS)
Centre for International Mobility (HV)
Contact:
Lari Lehtiö
Biocenter Oulu
Department of Biochemistry
Linnanmaa Campus
University of Oulu
FIN-90570 Oulu
Finland

Mailing address:
P.O. BOX
FIN-90014 University of Oulu
Finland

lari.lehtio-at-oulu.fi
Publications
Latest structure in the PDB


Updated 27.8.2012
mARTs in PDB

PARP-10 [ARTD10]
PARP domain: 3HKV RRM domain: 2DHX
PARP-11 [ARTD11]
WWE domain: 2DK6

PARP-12 [ARTD12]
PARP domain: 2PQF

PARP-13 [ARTD13]
PARP domain: 2X5Y

PARP-14 [ARTD8]
PARP domain: 3GOY, 3SMJ, 3SMI, 3SE2, 4F1L, 4F1Q macro domain: 3Q71, 3Q6Z, 3VFQ, 4D86, 4ABK, 4ABL, RRM domain: 1X5P WWE domain: 1XR4

PARP-15 [ARTD7]
PARP domain: 3GEY, 3BLJ, 4F0E macro domain 2: 3KH6, 3V2B

PARP-16 [ARTD15]
PARP domain: 4F0D