Publication list

Articles

  1. Kursula P., Lehto V.-P., Garbay B., Cassagne C. and Heape A.M. (1998) Expression of the amino acid dimorphism in the small myelin-associated glycoprotein cytoplasmic domain in rat peripheral nerves during postnatal development. Mol. Brain Res.54:252-261. [Published Erratum appears in Mol. Brain Res. (1998) 62:110].
  2. Heape A. M., Lehto V.-P. & Kursula P. (1999) The expression of recombinant large myelin-associated glycoprotein cytoplasmic domain and the purification of native myelin-associated glycoprotein from rat brain and peripheral nerve. Prot. Express. Purif. 15:349-361.
  3. Kursula P., Tikkanen G., Lehto V.-P., Nishikimi M. & Heape A.M. (1999) Calcium-dependent interaction between the large myelin-associated glycoprotein and S100b. J. Neurochem. 73: 1724-1732.
  4. Kursula P., Meriläinen G., Lehto V.-P. & Heape A.M. (1999) The small myelin-associated glycoprotein is a zinc-binding protein. J. Neurochem. 73: 2110-2118.
  5. Kursula P., Lehto V.-P. & Heape A.M. (2000) Estimation of total ribonucleic acid quantity from dilute samples by nondenaturing electrophoresis and silver staining. Electrophoresis 21: 545-547.
  6. Kursula P., Lehto V.-P. & Heape A.M. (2000) S100b inhibits the phosphorylation of the L-MAG cytoplasmic domain by PKA. Mol. Brain Res. 76: 407-410.
  7. Kursula P., Lehto V.-P. & Heape A.M. (2001) The small myelin-associated glycoprotein binds to tubulin and microtubules. Mol. Brain Res. 87: 22-30.
  8. Kursula P. (2001) The current status of structural studies on proteins of the myelin sheath. Int. J. Mol. Med. 8: 475-479.
  9. Kursula P., Ojala J., Lambeir A.-M. & Wierenga R.K. (2002) The catalytic cycle of biosynthetic thiolase: A conformational journey of an acetyl group through four binding modes and two oxyanion holes. Biochemistry 41: 15543-15556.
  10. Bhaumik P., Kursula P., Ratas V., Conzelmann E., Hiltunen J.K., Schmitz W. & Wierenga R.K. (2003) Crystallisation and preliminary X-ray diffraction analysis of 2-methylacyl-CoA racemase from Mycobacterium tuberculosis. Acta Cryst. D 59: 353-355.
  11. Pekkala M., Hieta R., Kursula P., Kivirikko K.I., Wierenga R.K & Myllyharju J. (2003) Crystallization of the proline-rich-peptide binding domain of human type I collagen prolyl 4-hydroxylase. Acta Cryst. D 59: 940-942.
  12. Kursula P. (2004) XDSi - a graphical interface for the data processing program XDS. J. Appl. Cryst. 37: 347-348.
  13. Kursula P., Sikkilä H., Fukao T., Kondo N. & Wierenga R.K. (2005) High resolution crystal structures of human cytosolic thiolase (CT). A comparison of the active sites of human CT, bacterial thiolase, and bacterial KAS I. J. Mol. Biol. 347: 189-201.
  14. Kursula I., Heape, A.M. & Kursula P. (2005) Crystal structure of non-fused glutathione S-transferase from Schistosoma japonicum in complex with glutathione. Protein Pept. Lett. 12: 709-712.
  15. Tzakos A.G., Kursula P., Theodorou V., Troganis A., Tselios T., Svarnas C., Matsoukas J., Apostopoulos V. & Gerothanassis I.P. (2005) Structure and function of the myelin proteins: Current status and perspectives in relation to multiple sclerosis. Curr. Med. Chem. 12: 1569-1587.
  16. Kursula P., Flodin S., Ehn M., Hammarström M., Schüler H., Nordlund P. & Stenmark P. (2006) Crystal structure of the synthetase domain of human CTP synthetase, a target for anticancer therapy. Acta Cryst. F 62: 613-617.
  17. Kursula P., Schüler H., Flodin S., Nilsson-Ehle P., Ogg D.J., Savitsky P., Nordlund P. & Stenmark P. (2006) Crystal structures of the hydrolase domain of human 10-formyltetrahydrofolate dehydrogenase and its complex with a substrate analogue. Acta Cryst. D 62: 1294-1299.
  18. Stanley W.A., Filipp F.V., Kursula P., Schüller N., Erdmann R,. Schliebs W., Sattler M. & Wilmanns M. (2006) Recognition of a functional peroxisome type 1 target by the dynamic import receptor Pex5p. Mol. Cell 24: 653-663.
  19. Stenmark P., Ogg D., Flodin S., Flores A., Kotenyova T., Nyman T., Nordlund P. & Kursula P. (2007) The structure of human collapsin response mediator protein 2, a regulator of axonal growth. J. Neurochem. 101:906-917.
  20. Stenmark P., Kursula P., Flodin S., Gräslund S., Landry R., Nordlund P. & Schüler H. (2007) Crystal structure of human inosine triphosphatase: Substrate binding and implication of the ITPA deficiency mutation P32T. J. Biol. Chem. 282: 3182-3187.
  21. Stanley W.A., Pursiainen N., Garman E.F., Juffer A., Wilmanns M. & Kursula P. (2007) A previously unobserved conformation for the human Pex5p receptor suggests roles for intrinsic flexibility and rigid domain motions in ligand binding. BMC Struct. Biol. 7: 24.
  22. Fukao T., Kursula P., Owen E.P & Kondo N. (2007) Identification and characterization of a temperature-sensitive R268H mutation in the human succinyl-CoA:3-ketoacid CoA transferase (SCOT) gene. Mol. Genet. Metab. 92: 216-221.
  23. Kursula P. & Majava V. (2007) A structural insight into lead neurotoxicity and calmodulin activation by heavy metals. Acta Cryst. F 63: 653-656.
  24. Kursula P., Kursula I., Massimi M., Song Y.-H., Downer J., Stanley W.A., Witke W. & Wilmanns M. (2008) High-resolution structural analysis of mammalian profilin 2a complex formation with two physiological ligands: the formin homology 1 domain of mDia1 and the proline-rich domain of VASP. J. Mol. Biol. 375: 270-290.
  25. Kursula P. (2008) Structural properties of proteins specific to the myelin sheath. Amino Acids 34: 175-185.
  26. Majava V., Petoukhov M.V., Hayashi N., Pirilä P., Svergun D.I. & Kursula P. (2008) Interaction between the C-terminal region of human myelin basic protein and calmodulin: Analysis of complex formation and solution structure. BMC Struct. Biol. 8: 10.
  27. Majava V., Löytynoja N., Chen W.-Q., Lubec G. & Kursula P. (2008) Crystal and solution structure, stability, and post-translational modifications of collapsin response mediator protein 2. FEBS J. 275: 4583-4596.
  28. Kursula I., Kursula P., Ganter M., Panjikar S., Matuschewski K. & Schüler H. (2008) Structural basis for parasite-specific functions of the divergent profilin of Plasmodium falciparum. Structure 16: 1638-1648.
  29. Meriläinen G., Schmitz W., Wierenga R. & Kursula P. (2008) The sulfur atoms of the substrate CoA and the catalytic cysteine are required for a productive mode of substrate binding in bacterial biosynthetic thiolase, a thioester-dependent enzyme. FEBS J. 275: 6136-6148.
  30. Zhang Z., Majava V., Greffier A., Hayes R.L., Kursula P. & Wang K.K.W. (2009) Collapsin response mediator protein-2 is a calmodulin binding protein. Cell. Mol. Life Sci. 66: 526-536.
  31. Haikarainen T., Chen W.-Q., Lubec G & Kursula P. (2009) Structure, modifications, and ligand-binding properties of rat profilin 2a. Acta Cryst. D 65: 303-311.
  32. Bertini I., Kursula P., Luchinat C., Parigi G., Vahokoski J., Wilmanns M. & Yuan J. (2009) Accurate solution structures of proteins from X-ray data and a minimal set of NMR data: calmodulin-peptide complexes as examples. J. Am. Chem. Soc. 131: 5134-5144.
  33. Majava V. & Kursula P. (2009) Domain swapping and different oligomeric states for the complex between calmodulin and the calmodulin-binding domain of calcineurin A. PLoS ONE 4: e5402.
  34. Behnen M., Murk K., Kursula P., Cappallo-Obermann H., Rothkegel M., Kierszenbaum A. & Kirchhoff C. (2009) Testis-expressed profilins 3 and 4 show distinct functional characteristics and localize in acroplaxome-manchette complex in spermatids. BMC Cell Biol. 10: 34.
  35. Myllykoski M., Kuczera K. & Kursula P. (2009) Complex formation between calmodulin and a peptide from the intracellular loop of the gap junction protein connexin43: molecular conformation and energetics of binding. Biophys. Chem. 144: 130-135.
  36. Meriläinen G., Poikela V., Kursula P. & Wierenga R. (2009) The thiolase reaction mechanism: the importance of Asn316 and His348 for stabilizing the enolate intermediate of the Claisen condensation. Biochemistry 48: 11011-11025.
  37. Majava V., Wang C., Myllykoski M., Kangas S.M., Kang S.U., Hayashi N., Baumgärtel P., Heape A.M., Lubec G. & Kursula P. (2010) Structural analysis of the complex between calmodulin and full-length myelin basic protein, an intrinsically disordered molecule. Amino Acids 39: 59-71.
  38. de Diego I., Kuper J., Bakalova N., Kursula P. & Wilmanns M. (2010) Molecular basis of the death associated protein kinase-calcium/calmodulin regulator complex. Science Signaling 3:ra6.
  39. Myllykoski M. & Kursula P. (2010) Expression, purification, and initial characterization of different domains of recombinant mouse 2',3'-cyclic nucleotide 3'-phosphodiesterase, an enigmatic enzyme from the myelin sheath. BMC Res. Notes 3:12.
  40. Knoll W., Natali F., Peters J., Nanekar R., Wang C. & Kursula P. (2010) Dynamic properties of a reconstituted myelin sheath. Spectroscopy, in press.
  41. Chen W.-Q., Salmazo A., Myllykoski M., Sjöblom B., Bidlingmaier M., Pollak A., Baumgärtel P., Djinovic-Carugo K., Kursula P. & Lubec G. (2010) Purification of recombinant growth hormone by clear native gels for conformational analyses - Preservation of conformation and receptor binding. Amino Acids, in press.
  42. Majava V., Polverini E., Mazzini A., Nanekar R., Knoll W., Peters J., Natali F., Baumgärtel P., Kursula I. & Kursula P. (2010) Structural and functional characterization of human peripheral nervous system myelin protein P2. PLoS ONE 5: e10300.
  43. Suresh S., Wang C., Nanekar R., Kursula P. & Edwardson J.M. (2010) Myelin basic protein and myelin protein 2 act synergistically to cause stacking of lipid bilayers. Biochemistry 49: 3456-3463.
  44. Fukao T., Ishii T., Amano N., Kursula P., Takayanagi M., Murase K., Sakaguchi N., Kondo N. & Hasegawa T. (2010) A neonatal onset succinyl-CoA:3-ketoacid CoA transferase (SCOT)-deficient patient with T435N and c.658-666dupAACGTGATT p.N220_I222dup mutations in the OXCT1 gene. J. Inherit. Metab. Dis., in press.
  45. Fukao T., Sass J.O., Kursula P., Thimm E., Wendel U., Ficicioglu C., Monastiri K., Guffon N., Baric I., Zabot M.T. & Kondo N. (2011) Clinical and molecular characterization of five patients with succinyl-CoA:3-ketoacid CoA transferase (SCOT) deficiency. Biochim. Biophys. Acta 1812: 619-624
  46. Patel A.K., Singh V.K., Bergmann U., Jagannadham M.V. & Kursula P. (2011) Purification, crystallization, and preliminary X-ray crystallographic analysis of MIL, a glycosylated jacalin-related lectin from mulberry (Morus indica) latex. Acta Cryst. F 67: 608-612.
  47. Patel A.K., Yadav R.P., Majava V., Kursula I. & Kursula P. (2011) Structure of the dimeric autoinhibited conformation of DAPK2, a pro-apoptotic protein kinase. J. Mol. Biol. 409: 369-383.
  48. Myllykoski M., Baumgärtel P. & Kursula P. (2011) Conformations of peptides derived from myelin-specific proteins in membrane-mimetic conditions probed by synchrotron radiation CD spectroscopy. Amino Acids, in press.
  49. Wang C., Neugebauer U., Bürck J., Myllykoski M., Baumgärtel P., Popp J. & Kursula P. (2011) Charge isomers of myelin basic protein: Structure and interactions with membranes, nucleotide analogues, and calmodulin. PLoS ONE 6: e19915.
  50. Patton G.C., Stenmark P., Gollapalli D.R., Sevastik R., Kursula P., Flodin S., Schüler H., Swales C.T., Eklund H., Himo F., Nordlund P. & Hedstrom L. (2011) Cofactor mobility determines reaction outcome in the IMPDH amd GMPR (β-α)8 barrel enzymes. Nature Chem. Biol. 7: 950-958.
  51. Ignatev A., Bhargav S.P., Vahokoski J., Kursula P. & Kursula I. (2012) The l asso segment is required for functional dimerization of the Plasmodium formin 1 FH2 domain. PLoS ONE, in press.
  52. Myllykoski M., Raasakka A., Han H. & Kursula P. (2012) Myelin 2',3'-cyclic n ucleotide 3'-phosphodiesterase: Active-site ligand binding and molecular conform ation. PLoS ONE, in press.
  53. Chen W.-Q., Heymann G., Kursula P., Rosner M., Hengstschläger M., Huppe rtz H. & Lubec G. (2012) The effects of gigapascal level pressure on protein str ucture and function. J. Phys. Chem. B, in press.
  54. Kuczera K. & Kursula P. (2012) Interactions of calmodulin with death-associa ted protein kinase peptides: experimental and modeling studies. J. Biomol. St ruct. Dyn., in press.

Ph.D. Thesis

Kursula P. (2000) Cytoplasmic domains of the myelin-associated glycoprotein. Acta Univ. Oul. D594. Oulu University Press, Oulu, Finland. online version

Book Chapters etc.

  1. Kursula P. (2001) Myeliinituppi - enemmän kuin osiensa summa (The myelin sheath - more than a sum of its parts). Avain 2/2001: 22-23.
  2. Kursula P. (2003) Myelin. In: Encyclopedia of the Neurological Sciences (Aminoff M.J. & Daroff R.B., eds.). Academic Press.
  3. Kursula P. (2003) Myelin proteins. In: Encyclopedia of the Neurological Sciences (Aminoff M.J. & Daroff R.B., eds.). Academic Press.
  4. Kursula P. (2003) Myelin disorders. In: Encyclopedia of the Neurological Sciences (Aminoff M.J. & Daroff R.B., eds.). Academic Press.
  5. Kursula P. (2003) Insights into the structure and function of the myelin-associated glycoprotein. In: Recent Research Developments in Neurochemistry (Pandalai S.G., ed.), vol. 6., pp. 65-80, Research Signpost, India.
  6. Kursula P. (2010) Structural biology insights into the autoantigens of the myelin sheath. In Autoimmune Diseases: Symptoms, Diagnosis and Treatment, Nova Publishers.

Communications at Various Congresses, Meetings, etc. (stopped counting around 2005)

  1. Kursula P., Lehto V.P. & Heape A.M., (1996). Amino acid dimorphism of the small myelin-associated glycoprotein isoform in the peripheral nervous system. Biocenter Day 1996, Oulu, Finland.
  2. Kursula P., Lehto V.P. & Heape A.M., (1996). Amino acid dimorphism of the small myelin-associated glycoprotein isoform in the peripheral nervous system. 11th meeting of the International Society of Developmental Neurosciences, Tampere, Finland.
  3. Heape A.M, Kursula P. & Lehto V.-P. (1997) Does the large myelin-associated glycoprotein form intracytoplasmic homodimers? Biocenter Day 1997, Oulu, Finland.
  4. Kursula P., Tikkanen G., Lehto V.-P. & Heape A.M. (1998) Effect of divalent cations on the binding of the myelin-associated glycoprotein cytoplasmic domains to peripheral nerve components. 32nd Scandinavian Congress of Neurology and 1st Scandinavian Congress of Neurologic Nursing, Oulu, Finland.
  5. Kursula P., Tikkanen G., Lehto V.-P. & Heape A.M. (1998) Divalent cations affect the binding of the MAG cytoplasmic tail to peripheral nerve components. 25th Silver Jubilee FEBS Meeting, Copenhagen, Denmark. (Oral presentation included)
  6. Heape A.M., Lehto V.-P. & Kursula P. (1998) Demonstration of a direct association of the small myelin-associated glycoprotein and tubulin. 28th Annual Meeting of the Society for Neuroscience, Los Angeles, USA. 
  7. Kursula P., Lehto V.-P. & Heape A.M. (1999) Phosphorylation of MAG and the effect of MAG on protein kinase autophosphorylation in vitro. 26th FEBS Meeting, Nice, France.
  8. Kursula P., Lehto V.-P. & Heape A.M. (1999) Studies on the function of the myelin-associated glycoprotein cytoplasmic domains. Joint ISN/ESN Meeting, Berlin, Germany.
  9. Kursula P., Ratas V., Glumoff T. & Wierenga R. (2000) The protein crystallography setup at the Oulu University. Proteins: From structures to properties with biocomputing approaches, Oulu, Finland.
  10. Wierenga R., Kursula P., & Mursula A. (2001) Structural studies of CoA-dependent enzymes: thiolase and isomerase. Biocenter Oulu Seminar Series. (Oral presentation)
  11. Kursula P., Ojala J. & Wierenga R. (2001) Structural enzymological studies on thiolases. 4th Nordic Meeting on medical and Biochemical Aspects of Lipid Metabolism. Rokua, Finland.
  12. Bhaumik P., Kursula P., Ratas V., Conzelmann E., Hiltunen J.K., Schmitz W. & Wierenga R.K. (2002) Crystallographic studies on 2-methylacyl-CoA racemase. RakBio Student and Post-Doc Meeting, Turku, Finland.
  13. Kursula P. & Hiltunen J.K. (2002) CoA-dependent enzymes: Structural studies. RAKBIO Final Meeting, Helsinki, Finland. (Oral presentation)
  14. Kursula P., Shani G., Kimchi A. & Wilmanns M. (2003) Crystal structure of human DRP-1 kinase. Protein Phosphorylation Workshop 2003, Asilomar, CA, USA.
  15. Kursula P., Gautel M., Johnson L.N., Kimchi A., Oikonomakos N., Vihinen M. & Wilmanns M. (2003) The CAMKIN research network. Protein Phosphorylation Workshop 2003, Asilomar, CA, USA.
  16. Stanley W.A., Filipp F.V., Kursula P., Svergun D.I., Sattler M. & Wilmanns M. (2004) Receptor recognition by the flexible peroxisomal targeting signal type 1 of sterol carrier protein 2. SBNet Conference 2004, Tällberg, Sweden, and 22nd European Crystallographic Meeting, Budapest, Hungary, and Structural Biology at Crossroads: From Biological Molecules to Biological Systems , Hamburg, Germany.
  17. Kursula P., Kursula I., Lehmann F., Consani Textor L., Zou P., Song Y.H. & Wilmanns M. (2004) Yeast SH3 domains: Structural genomics of a protein-protein interaction module. Structural Biology at Crossroads: From Biological Molecules to Biological Systems , Hamburg, Germany.
  18. Kursula P., Kursula I., Lehmann F., Zou P., Song Y.H. & Wilmanns M. (2004) Genome-wide crystallographic analysis of the folding space and ligand binding of yeast SH3 domains. International Conference on Structural Genomics, Washington, DC, USA.
  19. Stanley W.A., Filipp F.V., Kursula P., Svergun D.I., Sattler M. & Wilmanns M. (2005) Conformational flexibility in both receptor and cargo in type one peroxisomal targeting. Gordon Research Conference on Protein Transport Across Cell Membranes. New London, NH, USA.
  20. Zou P., Kursula P., Kursula I., Lehmann F., Song Y.H., Gonfloni S., Ferracuti S., Salmazo A., Textor L., Cesareni G., Serrano L. & Wilmanns M. (2005) The 3D proteome of SH3 domains from yeast. FEBS Workshop on Modular Protein Domains - From Functional Plasticity to Protein Linguistics. Seefeld, Austria.
  21. Stenmark P. Kursula P., Flodin S., Nyman T., Schüler H. & Nordlund P. (2006) Two roads to inosine monophosphate. 10th Annual Conference of the Swedish Structural Biology Network. Tällberg, Sweden.
  22. Fukao T., Sakurai S., Zhang G.-X., Yamada K., Kursula P., Mitchell G.A. & Kondo N. (2006) Mutation update of succinyl-CoA:3-ketoacid CoA transferase (SCOT) deficiency. 10th International Congress of Inborn Errors of Metabolism. Chiba, Japan.